Acetylcholinesterase Inhibitory Alkaloids from the Whole Plants of Zephyranthes carinata

作者：Zhan, Guanqun; Zhou, Junfei; Liu, Junjun; Huang, Jinfeng; Zhang, Hanqi; Liu, Rong; Yao, Guangmin^*

来源：Journal of Natural Products, 2017, 80(9): 2462-2471.

DOI：10.1021/acs.jnatprod.7b00301

• AMARYLLIDACEAE ALKALOIDS
• STRUCTURE REVISION
• NMR-SPECTRA
• N-OXIDES
• CANDIDA
• ANTIACETYLCHOLINESTERASE
• GALANTHAMINE
• CONSTITUENTS
• GRANDIFLORA
• CRINUM

Eleven new alkaloids (1-11), classified as the 12-acetylplicamine (1), N-deformyl-seco-plicamine (2), plicamine (3-6), 4a-epi-plicamine (7), seco-plicamine (8), and lycorine (9-11) framework types, along with 15 known alkaloids (12-26) were isolated from the whole plants of Zephyranthes carinata. The structures of the new alkaloids 1-11 were established by extensive spectroscopic data interpretation. The absolute configurations of 9 and 10 were defined by single-crystal X-ray diffraction analysis. Zephycarinatines A (1), B (2), and G (7) represent the first examples of 12-acetylplicamine, N-deformyl-seco-plicamine, and 4a-epi-plicamine alkaloids, respectively. Alkaloids 6, 11, 17, and 20-23 exhibited AChE inhibitory activities with IC50 values ranging from 1.21 to 184.05 mu M, and a preliminary structure-activity relationship is discussed.

• 出版日期2017-9
• 单位华中科技大学