Developmental Origin Governs CD8(+) T Cell Fate Decisions during Infection

作者：Smith Norah L; Patel Ravi K; Reynaldi Arnold; Grenier Jennifer K; Wang Jocelyn; Watson Neva B; Nzingha Kito; Mon Kristel J Yee; Peng Seth A; Grimson Andrew; Davenport Miles P; Rudd Brian D^*

来源：Cell, 2018, 174(1): 117-+.

DOI：10.1016/j.cell.2018.05.029

Heterogeneity is a hallmark feature of the adaptive immune system in vertebrates. Following infection, naive T cells differentiate into various subsets of effector and memory T cells, which help to eliminate pathogens and maintain long-term immunity. The current model suggests there is a single lineage of naive T cells that give rise to different populations of effector and memory T cells depending on the type and amounts of stimulation they encounter during infection. Here, we have discovered that multiple sub-populations of cells exist in the naive CD8(+) T cell pool that are distinguished by their developmental origin, unique transcriptional profiles, distinct chromatin landscapes, and different kinetics and phenotypes after microbial challenge. These data demonstrate that the naive CD8(+) T cell pool is not as homogeneous as previously thought and offers a new framework for explaining the remarkable heterogeneity in the effector and memory T cell subsets that arise after infection.

• 出版日期2018-6-28