A Ruthenium-Based Catalytic System for a Mild Borrowing-Hydrogen Process

作者：Jumde Varsha R; Gonsalvi Luca; Guerriero Antonella; Peruzzini Maurizio; Taddei Maurizio^*

来源：European Journal of Organic Chemistry, 2015, 2015(8): 1829-1833.

DOI：10.1002/ejoc.201403636

• Homogeneous catalysis
• Hydrogen transfer
• Alkylation
• Ruthenium
• Amines
• Alcohols

The alkylation of arylamines using stoichiometric amounts of aliphatic and benzylic alcohols in the presence of tBuOK was carried out at 55 degrees C using a low catalyst loading of [Ru(cod)Cl-2](n)/PTA (1,3,5-triaza-7-phosphaadamantane). The overall borrowing-hydrogen process does not require a controlled nitrogen atmosphere, and it could also be carried out at room temperature using higher loading of base. A wide range of substrates can be used in this transformation, and it has a good tolerance of different substituents. This catalytic system proved also to be efficient for other hydrogen-transfer reactions such as a tandem oxidation/C-C coupling between 1-phenylethanol and primary alcohols.

• 出版日期2015-3