New Insights into the Molecular Evolution of Metazoan Peroxiredoxins

作者：Bakiu Rigers^*; Santovito Gianfranco

来源：Acta Zoologica Bulgarica, 2015, 67(3): 305-317.

• peroxiredoxin
• metazoans
• molecular evolution

Peroxiredoxins (Prx) are enzymes present in all biological kingdoms, from bacteria to animals. The oxidised active site cysteine of Prx can be reduced by a cellular thiol, thus enabling Prx to function as a peroxidase. Peroxiredoxins have been object of an increasing interest for its pivotal role in cell defence and as conserved markers for circadian rhythms in metabolism across all three phylogenetic domains (Eukarya, Bacteria and Archaea). Metazoan cells express six Prx isoforms that are localised in various cellular compartments. Using bioinformatics tools, based on Bayesian approach, we analysed the phylogenetic relationships among metazoan Prxs, with the aim to acquire new data on the molecular evolution of these proteins. Peroxiredoxin molecular evolution analyses were performed by the application of Mr. Bayes and HyPhy software to the coding and protein sequences of deuterostomes and protostomes. The obtained results confirmed that the molecular evolution of metazoan Prx was peculiar and suggested that the positive selection may had operated for the evolution of these proteins and a purifying selection was present during this process.

• 出版日期2015-9