Mechanism of ribosome assisted protein folding: A new insight into rRNA functions

作者：Samanta Dibyendu; Das Anindita; Bhattacharya Arpita; Basu Arunima; Das Debasis; DasGupta Chanchal^*

来源：Biochemical and Biophysical Research Communications, 2009, 384(2): 137-140.

DOI：10.1016/j.bbrc.2009.04.106

• Protein folding by ribosome
• Domain V of 23S rRNA
• Ribosomal exit tunnel

The peptidyl transferase center (PTC), present in the domain V of 23S rRNA of bacteria can act as a general protein folding modulator. Any general function of a nucleic acid polymer (DNA or RNA) is always related to specific sequence/sequences. The ribosome mediated protein folding also involves a specific interaction between the nucleotides of peptidyl transferase center and the amino acids of an unfolded Protein. In this article the mechanism of rRNA assisted protein folding and its significance in the light of high resolution crystal structure of ribosome are discussed.

• 出版日期2009-6-26