Bilateral ovarian metastasis of non-small cell lung cancer with ALK rearrangement

作者：Fujiwara Ayako; Higashiyama Masahiko; Kanou Takashi; Tokunaga Toshiteru; Okami Jiro; Kodama Ken; Nishino Kazumi; Tomita Yasuhiko; Okamoto Isamu^*

来源：Lung Cancer, 2014, 83(2): 302-304.

DOI：10.1016/j.lungcan.2013.11.022

• Ovarian metastasis
• Non-small cell lung cancer
• ALK rearrangement

The discovery of a distinct subtype of non-small cell lung cancer (NSCLC) positive for rearrangement of the anaplastic lymphoma kinase gene (ALK) has had a substantial impact on personalized therapy for this disease. The clinical features associated with metastasis in individuals with ALK rearrangement-positive NSCLC remain to be fully characterized, however. We now describe a case of ovarian metastasis from NSCLC with ALK rearrangement. A 39-year-old woman underwent a right middle lobectomy for acinar-type adenocarcinoma of the lung (pT2aN2M0, stage IIIA). Fluorescence in situ hybridization (FISH) analysis of the resected tumor tissue revealed the presence of an ALK rearrangement. Twenty months later, a large intrapelvic mass was detected in the patient at follow-up. She underwent both left salpingo-oophorectomy and right ovarian cystectomy. Histological examination of the ovarian tumors showed acinar adenocarcinoma, and FISH analysis revealed the presence of ALK rearrangement, confirming a diagnosis of ALK rearrangement-positive NSCLC with ovarian metastasis. Although the ovary is an uncommon site for metastasis from lung cancer, physicians should be aware of the possibility for such metastasis during follow-up for female patients with ALK rearrangement-positive NSCLC. Further investigation is Warranted to clarify the incidence of ovarian metastasis in NSCLC patients with ALK rearrangement.

• 出版日期2014-2