科研之友
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摘要
Studies of expression of molecular chaperones of the family of Heat Shock Proteins 70 kDa ( HSP70) in the mouse and rat brain during sleep deprivation do not answer the question whether the HSP70 produce somnogenic effect. In the present work there are studied effects of exogenous Hsp70 that is known to be able to penetrate into living cells in vitro and to acquire properties of endogenous chaperone. Hsp70 was microinjected into the third brain ventricle of rats and pigeons at the beginning of the non-active 24-h phase when under natural conditions the sleep duration increases and the somato-visceral parameters decrease. Hsp70 has been established to enhance this natural process and to produce an additional increase of the total time of slow-wave sleep, a more pronounced inhibition of the muscle contractive activity, and a deeper decrease of the brain temperature. A similarity in effects of Hsp70 in rats and pigeons has been revealed. In both species the somnogenic Hsp70 action is realized by activation of mechanisms of maintenance of the longer episodes of the slow-wave sleep. The hypothermic Hsp70 effect seems to be associated with a decrease of the muscle contractive activity level, rather than with an enhancement of peripheral vasodilation and with an increase of heat loss. A hypothesis is put forward that the hyposedative/neuroleptic-like Hsp70 action that includes the somnogenic, myorelaxing, and hypothermic effects is mediated by activation of GABA(A) receptors of the main inhibitory brain system.
- 出版日期2008-2
