Stereoselective formation of (Z)-2-fluoroalkenoates via Julia-Kocienski reaction of aldehydes with pyrimidinyl-fluorosulfones

作者：Larnaud Florent; Pfund Emmanuel; Linclau Bruno; Lequeux Thierry^*

来源：Tetrahedron, 2014, 70(35): 5632-5639.

DOI：10.1016/j.tet.2014.06.081

• Fluoroalkenes
• Julia-Kocienski reaction
• Fluoroalkenoates
• Selective synthesis

The selective synthesis of fluoroalkenoates is reported from a pyrimidinyl fluorosulfone. This sulfone allowed the preparation of Z-fluoroalkenoates with very high stereoselectivity from both aromatic and aliphatic aldehydes. The nature of the heterocycle on the course of the Julia-Kocienski reaction is discussed.

• 出版日期2014-9-2