Novel fluorinated dialkylphosphonatocholines: Synthesis, physicochemical properties and antiprotozoal activities against Acanthamoeba spp.

作者：Lukac Milos^*; Garajova Maria; Mrva Martin; Devinsky Ferdinand; Ondriska Frantisek; Kubincova Janka

来源：Journal of Fluorine Chemistry, 2014, 164: 10-17.

DOI：10.1016/j.jfluchem.2014.04.008

• Critical micelle concentration
• Fluorinated surfactants
• Miltefosine
• Solubilization
• Trophocidal activity

The synthesis of four new organophosphorous gemini surfactants is presented. They belong to the class of dialkylphosphonatocholines. Tails are represented with two octyl groups both non or partially fluorinated. The synthesis was performed by reaction of alkylphosphonic acids with choline derivatives in the presence of 2,4,6-triisopropylbenzenesulfonyl chloride. The micellar, surface active, and solubilization properties of new surfactants were studied. Antiprotozoal activities were tested against Acanthamoeba lugdunensis and Acanthamoeba quina.

• 出版日期2014-8