nab-paclitaxel for the management of patients with advanced non-small-cell lung cancer

作者：Hirsh Vera^*

来源：Expert Review of Anticancer Therapy, 2014, 14(2): 129-141.

DOI：10.1586/14737140.2014.881719

• elderly
• histology
• nab-paclitaxel
• non-small-cell lung cancer
• taxanes

The 130 nm albumin-bound form of paclitaxel, nab-paclitaxel (Abraxane (R)), was recently approved by the US FDA for the first-line treatment of locally advanced or metastatic non-small-cell lung cancer (NSCLC) in combination with carboplatin in patients who are not candidates for curative surgery or radiation therapy. In a Phase III registrational trial, nab-paclitaxel plus carboplatin demonstrated a significantly improved overall response rate, the primary endpoint, and a trend toward improved survival compared with solvent-based paclitaxel plus carboplatin in patients with advanced NSCLC. Significantly less neutropenia, neuropathy, arthralgia, and myalgia were observed with the nab-paclitaxel regimen, but the solvent-based paclitaxel regimen produced less thrombocytopenia and anemia. The clinical experience with nab-paclitaxel to date and the role of this newly approved therapy in the management of NSCLC will be summarized in this article.

• 出版日期2014-2
• 单位McGill