H2AX: functional roles and potential applications

作者：Dickey Jennifer S^*; Redon Christophe E; Nakamura Asako J; Baird Brandon J; Sedelnikova Olga A; Bonner William M

来源：Chromosoma, 2009, 118(6): 683-692.

DOI：10.1007/s00412-009-0234-4

Upon DNA double-strand break (DSB) induction in mammals, the histone H2A variant, H2AX, becomes rapidly phosphorylated at serine 139. This modified form, termed gamma-H2AX, is easily identified with antibodies and serves as a sensitive indicator of DNA DSB formation. This review focuses on the potential clinical applications of gamma-H2AX detection in cancer and in response to other cellular stresses. In addition, the role of H2AX in homeostasis and disease will be discussed. Recent work indicates that gamma-H2AX detection may become a powerful tool for monitoring genotoxic events associated with cancer development and tumor progression.

• 出版日期2009-12