AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV

作者：Bhatt Aadra P; Damania Blossom^*

来源：Frontiers in Immunology, 2013, 3: 401.

DOI：10.3389/fimmu.2012.00401

• Akt
• KSHV
• mTOR
• PI3K
• B cells

As an obligate intracellular parasite, Kaposi sarcoma-associated herpesvirus (KSHV) relies on the host cell machinery to meet its needs for survival, viral replication, production, and dissemination of progeny virions. KSHV is a gammaherpesvirus that is associated with three different malignancies: Kaposi sarcoma (KS), and two B cell lymphoproliferative disorders, primary effusion lymphoma (PEL) and multicentric Castleman's disease. KSHV viral proteins modulate the cellular phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway, which is a ubiquitous pathway that also controls B lymphocyte proliferation and development. We review the mechanisms by which KSHV manipulates the PI3K/AKT/mTOR pathway, with a specific focus on B cells.

• 出版日期2013