Antitumor effect of boron nitride nanotubes in combination with thermal neutron irradiation on BNCT

作者：Nakamura Hiroyuki^*; Koganei Hayato; Miyoshi Tatsuro; Sakurai Yoshinori; Ono Koji; Suzuki Minoru

来源：Bioorganic & Medicinal Chemistry Letters, 2015, 25(2): 172-174.

DOI：10.1016/j.bmcl.2014.12.005

• Boron neutron capture therapy (BNCT)
• Boron nitride nanotubes (BNNTs)
• Antitumor effect
• B16 melanoma cells
• Colony-forming assay

The first BNCT antitumor effects of BNNTs toward B16 melanoma cells were demonstrated. The use of DSPE-PEG2000 was effective for preparation of the BNNT-suspended aqueous solution. BNNT-DSPE-PEG2000 accumulated in B16 melanoma cells approximately three times higher than BSH and the higher BNCT antitumor effect was observed in the cells treated with BNNT-DSPE-PEG2000 compared to those treated with BSH, indicating that BNNT-DSPE-PEG2000 would be a possible candidate as a boron delivery vehicle for BNCT.

• 出版日期2015-1-15