A hand hygiene intervention to decrease hand, foot and mouth disease and absence due to sickness among kindergarteners in China: A cluster-randomized controlled trial

作者：Liu, Xiaona^*; Hou, Wanli; Zhao, Zhiguang; Cheng, Jinquan^*; van Beeck, Ed F.; Peng, Xiaodong; Jones, Kylah; Fu, Xia; Zhou, Yan; Zhang, Zhen; Richardus, Jan Hendrik; Erasmus, Vicki

来源：Journal of Infection, 2019, 78(1): 19-26.

DOI：10.1016/j.jinf.2018.08.009

• Kindergarten
• Hand Hygiene
• Infectious disease control
• Youth health
• Community-based intervention

Objectives: : To evaluate the effect of the "Clean Hands, Happy Life" intervention on the incidence of hand, food and mouth disease (HFMD) and on school absences due to sickness in kindergarten students. @@@ Methods: : The intervention consisted of four hand hygiene (HH) promotion components and was evaluated in a cluster-randomized controlled trial among 8275 children and 18 kindergartens from May to October, 2015 in Shenzhen, China. We compared two intervention arms - received the intervention in kindergartens only and in both kindergartens and families, respectively - to the control arm in multilevel analyses. @@@ Results: : During the follow-up, the incidence of HFMD in both intervention arms was significantly lower than in the control arm (IRR1: 0.39, 95%CI: 0.26-0.59; IRR2: 0.30, 95%CI: 0.19-0.49); the duration of absence due to sickness (in days) in both intervention arms was significantly shorter than in the control arm (beta(1) = 0.58, 95%CI: 0.41-0.74; beta(2) = 0.34, 95%CI: 0.17-0.50), controlling for the area type of kinder- garten and grade level of children. Furthermore, during the follow-up we found that there were fewer episodes of absence due to respiratory, skin and eye infections (P < 0.05). @@@ Conclusions: : Our intervention is effective at reducing HFMD infections and absence due to sickness in children attending kindergartens in China.

• 出版日期2019-1
• 单位深圳市疾病预防控制中心