AN ENVIRONMENTALLY BENIGN AND SOLVENT-FREE SYNTHESIS OF 3-ARYL[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AND 1-ARYL-5-METHYL[1,2,4]TRIAZOLO[4,3-a]QUINOLINES USING PHENYLIODINE BIS(TRIFLUOROACETATE) OR IODOBENZENE DIACETATE

作者：Kumar P^*

来源：Chemistry of Heterocyclic Compounds, 2012, 47(10): 1237-1243.

DOI：10.1007/s10593-012-0899-0

• bridgehead triazoles
• hydrazones
• iodobenzene diacetate
• phenyliodine bis(trifluoroacetate)
• grinding
• oxidative cyclization
• solvent-free reactions

A simple, solvent-free and effective method for oxidative cyclization of 2-pyridyl-and 2-quinolyl-hydrazones with phenyliodine bis(trifluoroacetate) and iodobenzene diacetate to the corresponding 3-aryl[1,2,4]triazolo[4,3-a]pyridines and 1-aryl[1,2,4]triazolo[4,3-a]quinolines is described. All reactions were characterized by short reaction times and high yields at room temperature. All reactions were carried out by just grinding the reaction components.

• 出版日期2012-1