A metabolomics approach to evaluate the effects of shiitake mushroom (Lentinula edodes) treatment in undernourished young rats

作者：Molz Patricia; Ellwanger Joel Henrique; Iochims dos Santos Carla Eliete; Dias Johnny Ferraz; de Campos Deivis; Corbellini Valeriano Antonio; Pra Daniel; Lopes Putzke Marisa Terezinha; Rech Franke Silvia Isabel

来源：Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms , 2014, 318: 194-197.

DOI：10.1016/j.nimb.2013.05.108

• Mushroom
• Undernourishment
• PIXE
• FT-IR
• Elemental concentration

Undernourishment is characterized by a decrease of the metabolic rate as a result of lack of nutrients important to life. Shiitake mushroom (Lentinula edodes) can be an alternative to reverse undernourishment. The aim of this study was to explore the metabolic changes and consequent elemental concentrations found in undernourished rats and undernourished rats treated with shiitake mushroom (n = 12 rats each group). To determine the elemental concentration, blood samples were analyzed by Particle Induced X-ray Emission (PIXE). For metabolomics, blood samples were tested under Fourier Transform Infrared Spectroscopy (FT-IR). The results indicated that the supplementation with shiitake mushroom in undernourished rats altered the composition of blood proteins, elements and volume. Several strong correlations were observed between the elemental concentrations and metabolic parameters.

• 出版日期2014-1-1