Amperometric Biosensor and Front-End Electronics for Remote Glucose Monitoring by Crosslinked PEDOT-Glucose Oxidase

作者：Aleeva Yana; Maira Giovanni; Scopelliti Michelangelo; Vinciguerra Vincenzo; Scandurra Graziella; Cannata Gianluca; Giusi Gino; Ciofi Carmine; Figa Viviana; Occhipinti Luigi G; Pignataro Bruno^*

来源：IEEE Sensors Journal, 2018, 18(12): 4869-4878.

DOI：10.1109/JSEN.2018.2831779

• Amperometric sensors
• biosensors
• chemical and biological sensors
• conductive films
• polymer films
• remote sensing
• thick film biosensors

Focusing on the interplay between interface chemistry, electrochemistry, and integrated electronics, we show a novel low-cost and flexible biosensing platform for continuous glucose monitoring. The amperometric biosensing system features a planar three-electrode structure on a plastic substrate, and a wireless near-field communication-powered electronic system performing sensor analog front-end, A/D conversion, digital control, and display tasks. The working electrode is made of electropolymerized poly (3,4-ethylenedioxythiophene) film onto a polyethylene terephthalate/gold electrode followed by immobilization of cross-linked glucose oxidase by glutaraldehyde. The advantages offered by such a device, including low-cost materials and instrumentation as well as the good sensitivity of 9.24 mu A/(mM . cm(2)) are promising tools for point-of-care monitoring. It is demonstrated that the devices are good candidates for the development of advanced sensing approaches based on the investigation of the noise produced during operation (fluctuation-enhanced sensing).

• 出版日期2018-6-15