A cyclometalated iridium(III) complex that induces apoptosis in cisplatin-resistant cancer cells

作者：Wang, Jin-Quan^*; Hou, Xiao-Juan; Bo, Hua-Ben; Chen, Qi-Zhu

来源：Inorganic Chemistry Communications, 2015, 61: 31-34.

DOI：10.1016/j.inoche.2015.08.013

• Iridium(III) complex
• Platinum resistance
• ROS
• NF-kappa B
• Apoptosis

A novel cyclometalated iridium(Ill) complex, [Ir(C boolean AND N)(2)(HPIP)]Cl (IrC) was synthesized and characterized. IrC exhibited about 10-fold higher cytotoxicity than cisplatin against A549 cancer cell line. Interestingly, a cisplatin-resistant cell line, A549-CP/R showed sensitivity to IrC. Further study suggested that IrC induced apoptosis via negatively regulated the nuclear factor-kappa B (NF-kappa B) pathway, which involved reactive oxygen species (ROS) generation, Bd-2 and caspase family members activation. Taken together, these results suggest that IrC is able to overcome chemoresistance and may be an effective treatment for platinum-resistant cancer therapy.

• 出版日期2015-11
• 单位湖南医药学院; 广东药科大学