Associations between adiposity, hormones, and gains in height, whole-body height-adjusted bone size, and size-adjusted bone mineral content in 8-to 11-year-old children

作者:Dalskov S*; Ritz C; Larnkjaer A; Damsgaard C T; Petersen R A; Sorensen L B; Ong K K; Astrup A; Michaelsen K F; Molgaard C
来源:Osteoporosis International, 2016, 27(4): 1619-1629.
DOI:10.1007/s00198-015-3428-z

摘要

We examined fat-independent associations of hormones with height and whole-body bone size and mineral content in 633 school children. IGF-1 and osteocalcin predict growth in height, while fat, osteocalcin, and in girls also, IGF-1 predict growth in bone size. Leptin and ghrelin are inversely associated with bone size in girls. Obesity causes larger bone size and bone mass, but the role of hormones in this up-regulation of bone in obesity is not well elucidated. We examined longitudinal associations between baseline body fat mass (FM), and fat-independent fasting levels of ghrelin, adiponectin, leptin, insulin, insulin-like growth factor-I (IGF-1), osteocalcin, and intact parathyroid hormone, and subsequent changes in height and in whole-body height-adjusted bone area "BA(height)" and size-adjusted bone mineral content "BMCsize" in 8- to 11-year-olds. Analyses were carried out separately for boys (n = 325) and girls (n = 308) including data from baseline, 3 and 6 months from OPUS School Meal Study. In both sexes: gain in BA(height) was positively associated with baseline FM (a parts per thousand yen2.05 cm(2)/kg, both p a parts per thousand currency signaEuro parts per thousand 0.003). Furthermore, gain in height was positively associated with baseline IGF-1 (a parts per thousand yen0.02 cm/ng/ml, p = 0.001) and osteocalcin (a parts per thousand yen0.13 cm/ng/ml, p a parts per thousand currency signaEuro parts per thousand 0.009); and gain in BA(height) was positively associated with baseline osteocalcin (a parts per thousand yen0.35 cm(2)/ng/ml, p a parts per thousand currency signaEuro parts per thousand 0.019). In girls only, gain in BA(height) was also positively associated with baseline IGF-1 (0.06 cm(2)/ng/ml, p = 0.017) and inversely associated with both baseline ghrelin (-0.01 cm(2)/pg/ml, p = 0.001) and leptin (-1.21 cm(2)/mu g/ml, p = 0.005). In boys, gain in BMCsize was positively associated with osteocalcin (0.18 g/ng/ml, p = 0.030). This large longitudinal study suggests that in 8- to 11-year-old children, IGF-1 and osteocalcin predict growth in height, while FM, osteocalcin, and in girls also, IGF-1 predict growth in BA(height). Fat-independent inverse associations of leptin and ghrelin with BA(height in) girls' are contrary to proposed growth-stimulating effects of leptin. Osteocalcin in boys predicts gain in BMCsize.

  • 出版日期2016-4