An efficient indium-mediated 2-bromoallylation of aldehydes at low temperature in aqueous DMF

作者：Kim Yu Mi; Lee Sangku; Kim Sung Hwan; Kim Jae Nyoung^*

来源：Tetrahedron Letters, 2011, 52(25): 3240-3242.

DOI：10.1016/j.tetlet.2011.04.053

• 2-Bromoallylation
• Indium
• Barbier reaction
• Allene

An efficient synthesis of 2-bromohomoallylic alcohols was carried out via an indium-mediated Barbier-type 2-bromoallylation of aldehydes in moderate yields. The reaction was performed at low temperature (-20 degrees C) in aqueous DMF in order to minimize decomposition of 2-bromoallylindium reagent to allene.

• 出版日期2011-6-22