MUC1 Regulates Expression of Multiple microRNAs Involved in Pancreatic Tumor Progression, Including the miR-200c/141 Cluster

作者：Mohr Ashley M; Bailey Jennifer M; Lewallen Michelle E; Liu Xiang; Radhakrishnan Prakash; Yu Fang; Tapprich William; Hollingsworth Michael A^*

来源：PLos One, 2013, 8(10): e73306.

DOI：10.1371/journal.pone.0073306

MUC1 is a transmembrane glycoprotein that modulates transcription via its cytoplasmic domain. We evaluated the capacity of MUC1 to regulate the global transcription of microRNAs in pancreatic cancer cells expressing MUC1. Results indicated that MUC1 regulated expression of at least 103 microRNAs. We evaluated further regulation of the microRNA transcript cluster miR-200c/141, which was among the most highly regulated microRNAs. We found that MUC1 directly interacted with ZEB1, a known transcriptional repressor of the miR-200c/141 cluster, at the promoter of miR-200c/141, and further reduced transcript production. These data indicate that signaling through MUC1 influences cancer progression by regulating transcription of microRNAs that are associated with the process of metastasis.

• 出版日期2013-10-15
• 单位河北医科大学