Different thermodynamic signatures for DNA minor groove binding with changes in salt concentration and temperature

作者:Wang Shuo; Kumar Arvind; Aston Karl; Binh Nguyen; Bashkin James K; Boykin David W; Wilson W David*
来源:Chemical Communications, 2013, 49(76): 8543-8545.
DOI:10.1039/c3cc44569k

摘要

The effects of salt concentration and temperature on the thermodynamics of DNA minor groove binding have quite different signatures: binding enthalpy is salt concentration independent but temperature dependent. Conversely, binding free energy is salt dependent but essentially temperature independent through enthalpy-entropy compensation.

  • 出版日期2013