Maribavir Inhibits Epstein-Barr Virus Transcription through the EBV Protein Kinase

作者：Whitehurst Christopher B; Sanders Marcia K; Law Mankit; Wang Fu Zhang; Xiong Jie; Dittmer Dirk P; Pagano Joseph S^*

来源：Journal of Virology, 2013, 87(9): 5311-5315.

DOI：10.1128/JVI.03505-12

Maribavir (MBV) inhibits Epstein-Barr virus (EBV) replication and the enzymatic activity of the viral protein kinase BGLF4. MBV also inhibits expression of multiple EBV transcripts during EBV lytic infection. Here we demonstrate, with the use of a BGLF4 knockout virus, that effects of MBV on transcription take place primarily through inhibition of BGLF4. MBV inhibits viral genome copy numbers and infectivity to levels similar to and exceeding levels produced by BGLF4 knockout virus.

• 出版日期2013-5