Marine Pyrrolocarbazoles and Analogues: Synthesis and Kinase Inhibition

作者：Deslandes Sebastien; Chassaing Stefan; Delfourne Evelyne^*

来源：Marine Drugs, 2009, 7(4): 754-786.

DOI：10.3390/md7040754

• granulatimide
• isogranulatimide
• pyrrolocarbazole
• indolocarbazole
• kinase inhibitor

Granulatimide and isogranulatimide are alkaloids obtained from marine sources which have been shown to inhibit cell-cycle G2-checkpoint, targeting more particularly checkpoint 1 kinase (Chk1). At a structural level, they possess a characteristic pyrrolocarbazole framework also shared by the well-known rebeccamycin and staurosporine microbial metabolites which have been described to inhibit topoisomerase I and diverse kinases, respectively. This review reports precisely on the synthesis and kinase inhibitory activities of pyrrolocarbazole-based analogues of granulatimide.

• 出版日期2009-12