科研之友
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摘要
Objective: It remains uncertain whether leptin and adiponectin levels are correlated in maternal vs. fetal circulations. Little is known about whether leptin and adiponectin affect insulin sensitivity during fetal life. %26lt;br%26gt;Design and Methods: In a prospective singleton pregnancy cohort (n = 248), we investigated leptin and adiponectin concentrations in maternal (at 24-28 and 32-35 weeks of gestation) and fetal circulations, and their associations with fetal insulin sensitivity (glucose/insulin ratio, proinsulin level). %26lt;br%26gt;Results: Comparing concentrations in cord vs. maternal blood, leptin levels were 50% lower, but adiponectin levels more than doubled. Adjusting for gestational age at blood sampling, consistent and similar positive correlations (correlation coefficients: 0.31-0.34, all P %26lt; 0.0001) were observed in leptin or adiponectin levels in maternal (at 24-28 or 32-25 weeks of gestation) vs. fetal circulations. For each SD increase in maternal plasma concentration at 24-28 weeks, cord plasma concentration increased by 12.7 (95% confidence interval 6.8-18.5) ng/ml for leptin, and 2.9 (1.8-4.0) mu g/ml for adiponectin, respectively (adjusted P %26lt; 0.0001). Fetal insulin sensitivity was negatively associated with cord blood leptin (each SD increase was associated with a 5.4 (2.1-8.7) mg/dl/mu U/ml reduction in cord plasma glucose/insulin ratio, and a 5.6 (3.9, 7.4) pmol/l increase in proinsulin level, all adjusted P %26lt; 0.01) but not adiponectin (P %26gt; 0.4) levels). Similar associations were observed in nondiabetic full-term pregnancies (n = 211). %26lt;br%26gt;Conclusions: The results consistently suggest a maternal impact on fetal leptin and adiponectin levels, which may be an early life pathway in maternal-fetal transmission of the propensity to obesity and insulin resistance.
- 出版日期2013-1
