Bone muscle interactions and vitamin D

作者：Gunton Jenny E^*; Girgis Christian M; Baldock Paul A; Lips Paul

来源：Bone, 2015, 80: 89-94.

DOI：10.1016/j.bone.2015.02.029

• Vitamin D
• Muscle
• Bone
• Cross-talk
• Sarcopenia
• Osteoporosis

Beyond the established roles of vitamin D in bone and mineral homeostasis, we are becoming increasingly aware of its diverse effects in skeletal muscle. Subjects with severe vitamin D deficiency or mutations of the vitamin D receptor develop generalized atrophy of muscle and bone, suggesting coordinated effects of vitamin D in musculoskeletal physiology. At a mechanistic level, vitamin D exerts wide-ranging effects in muscle and bone calcium handling, differentiation and development. Vitamin D also modulates muscle and bone-derived hormones, facilitating cross-talk between these tissues. In this review, we discuss emerging evidence that vitamin D regulates bone and muscle in a direct, integrated fashion, positioning the vitamin D pathway as a potential therapeutic target for musculoskeletal diseases. This artide is part of a Special Issue entitled "Muscle Bone Interactions".

• 出版日期2015-11
• 单位河北医科大学