Association of the AA genotype of the BCL2 (-938C > A) promoter polymorphism with better survival in ovarian cancer

作者：Heubner Martin^*; Wimberger Pauline; Otterbach Friedrich; Kasimir Bauer Sabine; Siffert Winfried; Kimmig Rainer; Nueckel Holger

来源：International Journal of Biological Markers, 2009, 24(4): 223-229.

DOI：10.1177/172460080902400402

• BCL2
• Ovarian cancer
• Gene
• Polymorphism
• Promoter

Background: Bcl-2 plays a key role in the regulation of apoptosis. Recently, a novel regulatory single nucleotide polymorphism (-938C>A) in the inhibitory P2 BCL2 promoter was described. In this study we investigated its potential association with survival in epithelial ovarian cancer.
Experimental design: Patients (n=110) with primary epithelial ovarian cancer were retrospectively genotyped by pyrosequencing.
Results: Genotype distribution was not significantly different between 110 ovarian cancer patients and 120 healthy controls, suggesting that genotypes of this polymorphism do not increase the susceptibility to ovarian cancer. Kaplan-Meier curves showed a significant association of the AA genotype with increased survival (p=0.002). Multivariate analysis revealed that the BCL2-938AC/CC genotype (hazard ratio 4.5; p=0.003) was an independent prognostic factor compared to other prognostic factors such as age, histological grade or tumor stage.
Conclusion:The results suggest a role for the BCL2-938C>A polymorphism as a marker for survival in patients with epithelial ovarian cancer. (Int J Biol Markers 2009; 24: 223-9)

• 出版日期2009-12