Evaluation of the behaviour of fluorine-containing bioactive glasses: reactivity in a simulated body fluid solution assisted by multivariate data analysis

作者：Cocchi Marina; Durante Caterina; Lusvardi Gigliola^*; Malavasi Gianluca; Menabue Ledi

来源：Journal of Materials Science: Materials in Medicine , 2012, 23(3): 639-648.

DOI：10.1007/s10856-011-4543-9

Potentially bioactive fluorine-containing glasses of formula 46.2SiO(2)center dot 24.3Na(2)O center dot(26.9-x)CaO center dot 2.6P(2)O(5)center dot xCaF(2) [x = (0), 5, 10, 15] have been studied: the study was carried out as a function of fluorine percentage, dimensions and time of soaking in SBF. The results are compared to those obtained in the same conditions for Bioglass(A (R)) 45S5. Due to the high number and different kind of variables/conditions explored by this set of data, the results are rationalized for the first time by means of multivariate data analysis (MDA); in this way it is possible to classify the behaviour of bioglasses toward bioactivity. The presence of fluorine does not inhibit the formation of HA; in particular, for a fast bioactivity (in term of HA crystallization) it will be better to have large particle size or slabs, while for a fast dissolution fine particle sizes should be preferred.

• 出版日期2012-3