An Overview of Current Screening and Management Approaches for Prostate Cancer

作者：Akram Omar N; Mushtaq Gohar; Kamal Mohammad Amjad^*

来源：Current Drug Metabolism, 2015, 16(8): 713-718.

DOI：10.2174/1389200216666150812122430

• Castrate resistant prostate cancer
• epidemiology
• nano-medicine
• nano-technology
• prostate cancer
• prostate specific antigen
• therapy resistance

Prostate cancer is the fourth leading cause of mortality in Australian men. The prevalence and incidence is increasing in both developed and developing nations, thus there is a need for better screening and management of this disorder. While there is no direct known cause of prostate cancer, management is largely focused on early detection and treatment strategies. Of particular concern is advanced prostate cancer which can manifest as castrate resistant prostate cancer characterized by therapy resistance. This short review outlines the global epidemiology of prostate cancer, clinical manifestations, risk factors, current screening strategies including first line clinical screening as well as the use of circulating biomarkers, and treatment of prostate cancer through mainstream therapeutics as well as the cutting edge peptide and nano-technology based therapeutics that are being implemented or in the process of development to overcome therapeutic obstacles in the treatment of prostate cancer.

• 出版日期2015