Association of Saccade Duration and Saccade Acceleration/Deceleration Asymmetry during Visually Guided Saccade in Schizophrenia Patients

作者：Cui, Hong; Liu, Xiao-hui; Wang, Ke-yong; Zhu, Chun-yan; Wang, Chen; Xie, Xin-hui^*

来源：PLos One, 2014, 9(5): e97308.

DOI：10.1371/journal.pone.0097308

• ALERT SQUIRREL-MONKEY
• EYE-MOVEMENTS
• BURST NEURONS
• PHYSIOLOGY
• TRACKING
• VELOCITY
• ANATOMY

Objective: To examine the difference between schizophrenia patients and normal controls on velocity and acceleration of saccade, by using the basic visually guided saccade (VGS) paradigm.
Methods: Eighteen schizophrenia outpatients and fourteen normal controls participated in the VGS task. Multiple indicators, including amplitude, duration, velocity, latency, accuracy rate, acceleration, and deceleration were analyzed. Asymmetric acceleration index (AAI) was introduced to describe the difference between peak acceleration and peak deceleration. The correlation coefficient (R-AD) of AAI and duration was computed to examine the difference between schizophrenia patients and normal controls.
Results: No significant difference between patients and normal controls was found on amplitude, duration, latency, and accuracy rate. However, RAD values of schizophrenia patients were significantly lower than the control group.
Conclusion: Compared to normal controls, association of saccade duration and saccade acceleration/deceleration asymmetry during visually guided saccade was lower in schizophrenia patients.

• 出版日期2014-5-16
• 单位上海市精神卫生中心; 中国人民解放军总医院; 安徽医科大学