科研之友
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摘要
Malaria remains one of the world's principal infectious diseases, with an enormous burden of morbidity and mortality associated. The neurological manifestations that can be seen in its most severe forms are very wide-ranging, being cerebral malaria its paradigmatic syndrome. This encephalopathy, which differs substantially in children and adults, usually presents with an altered level of consciousness, convulsions, retinopathy, and brainstem signs with or without concomitant intracranial hypertension. As many as 20% of all cerebral malaria cases are fatal, and among those surviving, up to 10% may develop neurological sequelae that may occasionally be severe, or more frequently include transitory neurological deficits. There is increasing evidence, however, that cerebral malaria may be responsible for more subtle neurocognitive disorders. Despite a current better understanding of the pathogenesis of this syndrome, no adjuvant therapies, proposed on the basis of the current physiopathological knowledge, has shown to improve its prognosis. The adequate use of effective antimalarial drugs, and supportive therapy for the concomitant complications, remains the cornerstone of the management of this syndrome.
- 出版日期2008-12
