Development and regulatory application of microRNA biomarkers

作者：Krauskopf Julian; Verheijen Marcha; Kleinjans Jos C; de Kok Theo M; Caiment Florian

来源：Biomarkers in Medicine, 2015, 9(11): 1137-1151.

DOI：10.2217/bmm.15.50

• biomarker
• cardiotoxicity
• circulating miRNAs
• drug safety testing
• environmental exposure
• hepatotoxicity
• microRNA

MicroRNAs, a class of regulatory small non-coding RNAs, are emerging as promising biomarkers for different health outcomes. Due to their tissue specificity, stability in extracellular space and high conservation between preclinical test species, applications of novel miRNA-based biomarkers for drug safety testing regarding hepatotoxicity and cardiotoxicity are investigated. Furthermore, miRNA expression is altered by environmental exposure such as cigarette smoke or polychlorinated biphenyls. As a consequence, miRNAs potentially influence tumor suppressor genes and oncogenes and may influence carcinogenesis. This has raised the interest in the use of miRNA profiles for health risk assessment. This review summarizes the recent developments in miRNA research with focus on biomarkers for drug safety testing and biomarkers for health outcomes related to environmental exposures.

• 出版日期2015