Association of fatty liver with cardiovascular risk factors and subclinical atherosclerosis in a Mexican population

作者：Martinez Alvarado Maria del Rocio; Gabriel Juarez Rojas Juan; Xochitl Medina Urrutia Aida; Celestino Cardoso Saldana Guillermo; del Carmen Gonzalez Salazar Maria; Posadas Sanchez Rosalinda; Jorge Galarza Esteban; Mendoza Perez Enrique; Vargas Alarcon Gilberto; Posadas Romero Carlos^*

来源：Revista de Investigacion Clinica, 2014, 66(5): 407-414.

• Fatty liver
• Subclinical atherosclerosis
• Insulin resistance

Introduction. Individuals with fatty liver (FL) have an increased risk of coronary artery disease (CAD) probably due to its association with cardiometabolic risk factors (CMRF). Objective. To know the prevalence of FL and analyze its association with CMRF and subclinical atherosclerosis, in a sample of Mexican Mestizo population. Material and methods. This study included 846 subjects from the Genetic of Atherosclerosis Disease (GEA) study (53 +/- 9 years, 50.7% women) without diabetes and no personal or family history of premature CAD. Blood samples were taken for measurements of lipids profile, uric acid, and insulin. The presence of FL was identified by computed tomography. Carotid intima media thickness (CIMT) was measured by B mode ultrasound, using the > 75 percentile as cutoff value to define subclinical atherosclerosis. Results. The general prevalence of FL was 32.4%. In men, FL was associated with hyperuricemia, whereas in women, hyperuricemia, low level of high density lipoprotein cholesterol, and metabolic syndrome were the factors associated with this hepatic alteration. In women, FL was associated with a 66% higher probability of having high CIMT, independently of age, hypertension, dyslipidemia, and waist circumference, but not of HOMA-IR. Conclusions. In women, FL was associated with the presence of subclinical atherosclerosis independently of traditional CMRF. Our study suggests that, in women, insulin resistance could be a mediator of metabolic abnormalities and of subclinical atherosclerosis.

• 出版日期2014-10