A Novel Recombinant Fusion Protein Exhibited Inhibitory Activities on Platelet Aggregation and Thrombin

作者：Hu Zongli; Zhao Zhiping; Liang Yan; Li Yong; Chen Guoping^*

来源：Letters in Drug Design and Discovery, 2010, 7(3): 182-187.

DOI：10.2174/157018010790596605

• Thrombosis
• Hirudin 12-residue
• Thrombin
• NAP5
• Platelet aggregation
• Recombinant fusion protein

We designed a novel recombinant fusion protein r-NAP5-hirudin 12-residue- RGD with bi-functional inhibitory activities against platelet aggregation and thrombin. Our strategy may supply a potential multi-functional drug for the prevention and management of thrombosis.

• 出版日期2010-3
• 单位重庆大学