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摘要
An asymmetric doubly vinylogous Michael addition (DVMA) of alpha,beta-unsaturated gamma-butyrolactams to sterically congested beta-substituted cyclic dienones with high site-, diastereo-, and enantioselectivity has been achieved. An unprecedented DVMA/vinylogous Michael addition/isomerization cascade reaction affords chiral fused tricyclic gamma-lactams with four newly formed stereocenters.
- 出版日期2015-8-24
- 单位华东理工大学
