A case of hyperparathyroidism-associated parkinsonism successfully treated with cinacalcet hydrochloride, a calcimimetic

作者：Ohya Yuichiro^*; Osaki Masato; Sakai Shota; Kimura Shunsuke; Yasuda Chiharu; Ago Tetsuro; Kitazono Takanari; Arakawa Shuji

来源：BMC Neurology, 2018, 18(1): 62.

DOI：10.1186/s12883-018-1067-7

• Cinacalcet
• Hypercalcemia
• Hyperparathyroidism
• Parkinsonism

Background: Some metabolic disorders, including abnormal calcium metabolism, can develop and worsen parkinsonism. However, whether hyperparathyroidism can cause parkinsonism remains controversial.
Case presentation: An 83-year-old woman with a history of right thalamic hemorrhage and drug-induced parkinsonism, was admitted due to worsening of parkinsonian symptoms including mask-like face, bradykinesia, freezing of gait, and rigidity. She had been diagnosed with autoimmune hepatitis and was being treated with prednisolone. Examinations revealed hypercalcemia (14.3 mg/dL) with an increased level of intact parathyroid hormone (iPTH) (361 pg/mL). Her symptoms were resistant to some additional anti-parkinsonian drugs; however, cinacalcet hydrochloride, a calcimimetic for the treatment of secondary hyperparathyroidism, normalized levels of serum calcium and iPTH, and remarkably improved her symptoms.
Conclusions: In the present case, we speculate that hypercalcemia probably due to secondary hyperparathyroidism that had developed during steroid therapy deteriorated the parkinsonism.

• 出版日期2018-5-7