科研之友
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摘要
Cartilage does not form in the tooth extraction socket of the normal rat The aim of the study was to determine if adding BMP-6 to the extraction socket would cause chondrogenic differentiation in the diabetic rat
A group of 8-week-old rats were injected intraperitoneally with a diabetogenic agent, streptozotocin, and a control group received citrate buffer only Three weeks later, the maxillary molar teeth were extracted and either BMP-6 or saline applied to the extraction sockets Rats from each group were killed on days 3, 5, 7, and 9 after tooth extraction In the diabetic rats treated with BMP-6, there was a cellular subperiosteal reaction at day 3 in the extra-alveolar tissues, which by day 7 had formed a large mass of cartilage
Cartilage was induced in the subperiosteal region of the socket extra-alveolar bone following the application of BMP-6 in the diabetic rat
- 出版日期2010-12
