Admission Glucose and Risk of Early Death in Non-Diabetic Patients with ST-Segment Elevation Myocardial Infarction: A Meta-Analysis

作者：Zhao, Cheng-jin^*; Hao, Zhen-xuan; Liu, Rong; Liu, Yang

来源：MEDICAL SCIENCE MONITOR, 2015, 21: 1387-1394.

DOI：10.12659/MSM.894249

• Blood Glucose
• Meta-Analysis
• Myocardial Infarction

Background: Impaired admission glucose (AG) is considered to significantly increase risk on both early and late death of the patients with ST-segment elevation myocardial infarction (STEMI), especially for non-diabetic patients; however, some reports contradict the relationship. We therefore conducted a meta-analysis to clarify this issue.
Material/Methods: PubMed, EMBASE, Web of Science, and Cochrane Library databases were systematically searched to identify all related prospective cohort studies. The relative risks (RR) with their 95% confidence interval (CI) were pooled quantitatively.
Results: The pooled RR of early outcome events indicated patients with glucose concentrations 3 6.1-11.1 mmol/L had a 4.38-fold (95% CI, 3.23-5.94) higher early mortality. The pooled RR of late outcome events indicated that the patients with glucose concentrations >= 7.8-11.1 mmol/L had a 1.65-fold (95% CI, 1.33-2.04) higher late mortality based on in-hospital or 30-day survivors.
Conclusions: High AG may be a helpful prognostic marker of significantly increased risk on early death in non-diabetic patients with STEMI, and has an explicit but prognostic adverse impact on long-term mortality but not early mortality in these patients.

• 出版日期2015-5-14
• 单位南方医科大学; 西安交通大学; 陕西省人民医院