Microcalorimetric study of the effect of l-borneol, d-borneol and synthetic borneol on the growth of P-aeruginosa

作者：Ma, Xiao; Xie, Qian; Wu, Mingquan; Zhao, Yanling; Wang, Jian^*; Wen, Jianxia; Ma, Rong; Dong, Taiwei

来源：Journal of Thermal Analysis and Calorimetry, 2018, 131(2): 1681-1689.

DOI：10.1007/s10973-017-6627-3

• Borneol
• Drugs property
• P. aeruginosa
• Microcalorimetry

Properties theory of traditional Chinese medicine has been used thousands of years. Borneol, an important drug, was widely used for acute illness-"Rebi" in Chinese. However, in Chinese Pharmacopoeia (Ch.P), borneol is recorded as three kinds: l-borneol (B-1), d-borneol (B-2) and synthetic borneol (B-3). In the study, the power-time (P-t) curves generated by P. aeruginosa which were disturbed by borneol were investigated through microcalorimetry; afterward, some thermo-kinetic parameters were obtained from the curves to characterize the metabolism of P. aeruginosa. The parameters were analyzed by principal component analysis. The results showed that borneol expressed different drugs properties. The half-maximal influences concentration (IC50) value of B-1 was lower than those of B-2 and B-3. Especially, the IC50 of B-1 was 447.185 mu g mL(-1). The influences of three kinds of borneol were l-borneol (B-1) > synthetic borneol (B-3) > d-borneol (B-2), which met the long-term cognition. This could provide guidance for clinical use of borneol with different drugs properties.

• 出版日期2018-2
• 单位成都中医药大学; 中国人民解放军第三０二医院