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摘要
Relationship between atopy and asthma is complex. Studies evaluating association between markers of atopy with asthma severity or lung function tests have failed to yield consistent results. A prospective cohort study was done at the Pediatric Chest Clinic at tertiary care university hospital, Delhi, India. Children with physician diagnosed, moderate to severe persistent asthma, between 5 and 15 years of age, were enrolled from May 2007 to June 2009. Sensitization to aeroallergens was assessed by the skin prick test using 12 common aeroallergens. Asthma was managed according to the National Asthma Education and Prevention Program-Expert Panel Report 3 guidelines and children were followed up as a cohort every 2 months for 6 months. Correlation between aeroallergen sensitization, atopic markers with asthma severity, and treatment outcome was studied. Seventy-eight (57 boys) patients with mean age of 109 +/- 27 months were subjected to the skin prick test. Forty-nine (62.8%) children were sensitized to at least one aeroallergen. Common aeroallergens to which children were sensitized: cockroach (37%), rice dust (31%), mosquito (29%), housefly (29%). Sensitized patients had a higher rate of breathlessness, seasonal symptoms, and atopic dermatitis than those who were nonsensitized, (P%26lt;0.05). Children with high absolute eosinophil count had decreased spirometry parameters after 6 month of follow up, (P=0.04). Sensitization rates were independently associated with children having breathlessness (P=0.04) and seasonal symptoms (P=0.01). No significant association was found between sensitization, asthma severity, and treatment outcome. Aeroallergen sensitization was found in two-third patients. The most common aeroallergens were insects and rice dust. Sensitization was neither related to asthma severity nor to asthma control.
- 出版日期2013-12-1
- 单位河北医科大学
