Association of anti-CCP positivity with serum ferritin and DAS-28

作者：Onder Burcu^*; Kurtaran Aydan; Kimyon Songuel; Selcuk Barin; Akyuz Muefit

来源：Rheumatology International, 2009, 30(2): 223-227.

DOI：10.1007/s00296-009-0941-4

• Rheumatoid arthritis
• Anti-CCP antibodies
• Ferritin
• Disease activity
• Rheumatoid factor

Antibodies to cyclic citrullinated peptides (anti-CCP) are highly specific for the diagnosis of rheumatoid arthritis (RA) with a marginal increased prediction of the disease. In this study, we aimed to investigate the relation of the presence of anti-CCP with clinical manifestations and disease activity in a cohort of RA patients. A total of 61 RA patients were included in this study. Data of disease-related parameters such as duration of disease, medications, degree of pain (visual analog scale, VAS), disease activity score 28 (DAS-28) and health assessment questionnaire (HAQ) were recorded. Laboratory workup included erythrocyte sedimentation rate (ESR), plasma C-reactive protein (CRP), rheumatoid factor (RF), anti-CCP, complete blood count and anemia parameters. Anti-CCP positivity was associated with higher scores of DAS-28, longer duration of morning stiffness, serum RF positivity and low levels of serum ferritin, while it was not associated with disease duration, VAS, HAQ, ESR, CRP and hemoglobin.

• 出版日期2009-12