Analysis of Amaryllidaceae Alkaloids from Zephyranthes robusta by GC-MS and Their Cholinesterase Activity

作者：Cahlikova Lucie^*; Kulhankova Andrea; Urbanova Klara; Valterova Irena; Macakova Katerina; Kunes Jiri

来源：Natural Product Communications, 2010, 5(8): 1201-1204.

• Zephyranthes robusta
• Amaryllidaceae
• GC/MS
• acetylcholinesterase
• butyrylcholinesterase

From the bulbs of Zephyranthes robusta Baker (Amaryllidaccae), seven known compounds, belonging to four structural types of Amaryllidaceae alkaloids, were identified and quantified by GC-MS. The alkaloid extract from the bulbs showed promising acetylcholinesterase and butyrylcholinesterase inhibitory activities against HuAChE (IC(50) = 35.9 +/- 3.5 mu g/mL) and HuBuChE (IC(50) = 190.9 +/- 8.2 mu g/mL).

• 出版日期2010-8