Tincture of opium for treating opioid dependence: a systematic review of safety and efficacy

作者：Nikoo Mohammadali^*; Nikoo Nooshin; Anbardan Sanam Javid; Amiri Afshar; Vogel Marc; Choi Fiona; Sepehry Amir Ali; Valoojerdi Amir Hooshang Bagheri; Jang Kerry; Schutz Christian; Akhondzadeh Shahin; Krausz Michael

来源：Addiction, 2017, 112(3): 415-429.

DOI：10.1111/add.13628

• Medication-assisted treatment
• opiate dependence
• opioid dependence
• opium
• review
• substance use
• tincture of opium
• treatment

Background and Aims Recently, there has been a growing interest in using opium tincture (OT) for treating opioid dependence in certain regions. We aimed to assess the evidence on its safety and efficacy for this indication. Methods We searched several databases (CENTRAL, Medline, EMBASE, Web of Science, PsychINFO, ProQuest Dissertation and Theses Database, Iran Medex, clinicaltrials.gov and who.int/trialsearch) with no language or publication date limitations. Two reviewers selected randomized controlled trials (RCT), cohort/case-control/cross-sectional studies and case-series on safety or efficacy of OT for treating opioid dependence and then extracted reported measures of mentioned outcomes from selected studies. We used the Effective Public Health Practice Project (EPHPP) Quality Assessment tool for appraisal. Results From nine selected studies; in three RCTs and one cohort analytical analysis on detoxification, 110 patients were treated with 15-140 morphine equivalents/day (mEq/d) of OT; in four prospective and one retrospective uncontrolled case-series on long-term/maintenance treatment, 570 patients were treated with 100-400 mEq/d of OT. Only two studies on detoxification included a comparison: one concluded equal efficacy of OT and methadone in suppressing withdrawal symptoms (P = 0.32) and the other concluded OT to be less efficacious than buprenorphine/naloxone in suppressing withdrawal [OT = 12.20, 95% confidence interval (CI) = 11.00, 13.40]; control: 5.20 (95% CI = 4.69, 5.71) and craving (OT = 303.0, 95% CI = -144.664, 750.664; control: 0.0) but not significantly different (P = 0.26) in retaining participants in treatment. No major adverse events were reported. Conclusions Conclusive recommendations about the safety and efficacy of opium tincture for treating opioid dependence are not possible at this time.

• 出版日期2017-3