Animal Models of Carcinogenesis in Inflamed Colorectum: Potential Use in Chemoprevention Study

作者：Tanaka Takuji^*

来源：Current Drug Targets, 2012, 13(14): 1689-1697.

DOI：10.2174/138945012804545452

• Inflammation and cancer
• inflammatory bowel disease
• colorectal cancer
• chemoprevention
• animal model

Inflammation is a risk factor for cancer development in several tissues. In the colorectum, inflammatory bowel disease (ulcerative colitis and Crohn%26apos;s disease) is a longstanding inflammatory disease with increased risk for colorectal cancer (CRC). Several molecular events involving in chronic inflammatory process contribute to multi-stage carcinogenesis of CRC in the inflamed colon. They include alterations in production of reactive oxygen and nitrogen species, up-regulation of pro-inflammatory cytokines and inflammatory enzymes, and intestinal immune system. In this short review, experimental animal models of inflammation-associated CRC are described. Also, some preclinical data on chemoprevention of inflammation-associated CRC by astaxanthin and a specific inhibitor of nitric oxide synthase using these inflammation-related -CRC models is briefly introduced.

• 出版日期2012-12