Divergent effects of central melanocortin signalling on fat and sucrose preference in humans

作者：van der Klaauw Agatha A; Keogh Julia M; Henning Elana; Stephenson Cheryl; Kelway Sarah; Trowse Victoria M; Subramanian Naresh; O' Rahilly Stephen; Fletcher Paul C; Farooqi I Sadaf

来源：Nature Communications, 2016, 7(1): 13055.

DOI：10.1038/ncomms13055

Melanocortin-4-receptor (MC4R)-expressing neurons modulate food intake and preference in rodents but their role in human food preference is unknown. Here we show that compared with lean and weight-matched controls, MC4R deficient individuals exhibited a markedly increased preference for high fat, but a significantly reduced preference for high sucrose food. These effects mirror those in Mc4r null rodents and provide evidence for a central molecular circuit influencing human macronutrient preference.

• 出版日期2016-10-4