Design and synthesis of 3-[3-(substituted phenyl)-4-piperidin-1-ylmethyl/-4-morpholin-4-ylmethyl-4,5-dihydro-isoxa zol-5-yl]-1H-indoles as potent anti-inflammatory agents

作者：Amir Mohammad^*; Javed Sadique Akhtar; Kumar Harish

来源：Medicinal Chemistry Research, 2010, 19(3): 299-310.

DOI：10.1007/s00044-009-9194-8

• Indole
• Isoxazoline
• Anti-inflammatory
• Ulcerogenicity
• Lipid peroxidation

The synthesis of new indole derivatives bearing isoxazoline moiety (3a-d and 4a-d) has been described. IR, (1)H NMR, and mass spectral data supported the structures of synthesized compounds. The compounds were tested in vivo for their anti-inflammatory activity by carrageenin-induced rat paw edema method. The compounds that showed good anti-inflammatory activity were screened for their ulcerogenic and lipid peroxidation activities. The most active compound of this series is 3-[3-(4-methoxyphenyl)- 4-morpholin-4-ylmethyl)-4,5-dihydro-isoxazol-5yl]-1H-indole 4d.

• 出版日期2010-4