An efficient one-pot synthesis of 2-benzylpyrroles and 3-benzylindoles

作者：Sharma Ratnesh; Chouhan Mangilal; Sood Divya; Nair Vipin A^*

来源：Applied Organometallic Chemistry, 2011, 25(4): 305-309.

DOI：10.1002/aoc.1759

• benzylation
• zirconium(IV) chloride
• pyrrole
• indole

One-pot regioselective benzylation of pyrroles and indoles using zirconium tetrachloride is discussed. This has been achieved by in-situ generation of di(1H-pyrrol-1-yl)zirconium(IV) chloride and di(1H-indol-1-yl)zirconium(IV) chloride. It was observed that benzylation reactions of these complexes using n-BuLi occurred at C-2 position for pyrrole and C-3 for indole.

• 出版日期2011-4