A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide-induced anemic rats

作者：Zhang, Li; Gong, Amy G. W.; Riaz, Kashif; Deng, Jun Y.; Ho, Chih M.; Lin, Huang Q.; Dong, Tina T. X.; Lee, Yi-Kuen; Tsim, Karl W. K.^*

来源：FEBS Open Bio, 2017, 7(3): 318-323.

DOI：10.1002/2211-5463.12146

• feedback system control
• flavonoids combination
• hematological parameters

By using a feedback system control scheme, the best combination of formononetin, ononin, calycosin, and calycosin-7-O-beta-D-glucoside derived from Astragali Radix was shown to activate a hypoxia response element, a regulator for erythropoietin (EPO) transcription, in kidney fibroblast. In cyclophosphamide-induced anemic rats, the treatment of combined flavonoids, or EPO, improved the levels of red blood cells, white blood cells, hemoglobin, and hematocrit. In addition, the altered levels of antioxidant capacity, super oxidase dismutase, and malondialdehyde, triggered in anemic rats, were restored to control levels by the treatment of flavonoids. Here, we proposed a possible therapy by using the common flavonoids in treating anemia.

• 出版日期2017-3
• 单位香港科技大学深圳研究院; 香港科技大学; 上海中医药大学