A New 3D Ba(II)-Based Metal-Organic Framework as Anticancer Drug 5-Fu Carrier and Anti-Liver Cancer Study

作者：Lin, Xiu-Qing; Huang, Zhi-Ming; Chen, Xin; Wu, Fang; Jin, Rui-Fang; Wu, Wei^*

来源：Latin American Journal of Pharmacy, 2018, 37(6): 1162-1167.

• anticancer activity
• coordination polymer
• encapsulation
• MTT assay

The solvothermal reactions of barium nitrate and 4,4',4 ''-(1,3,5-triazine-2,4,6-triyl) tribenzoic acid (H(3)TATB) in a mixed solvent of N, N-Dimethyl formamide (DMF) and H2O at 120 degrees C leads to the formation of a new Ba(II)-based coordination polymer Ba(HTATB)(H2O)](DMF) 2 (1) based on the ligand as a C-3 symmetric 3-connected organic node and the Ba2+ ion as 5-connected node. The efficient encapsulation of an anticancer drug 5-fluorouracil (5-Fu) on the desolvated 1 (1a) has been studied by grand canonical Monte Carlo (GCMC) simulation. In addition, the MTT assay method was assessed the ability of this drug delivery system on liver cancer HepG2 cells as well as the cytotoxicity of the carrier, which show that this drug loaded system exhibits very high biocompatibility and, hence, is promising as intracellular drug delivery carriers.

• 出版日期2018
• 单位温州医科大学