Antiangiogenic therapy for primary and metastatic brain tumors

作者：Purow B; Fine HA^*

来源：Hematology-Oncology Clinics of North America, 2004, 18(5): 1161-+.

DOI：10.1016/j.hoc.2004.05.003

We first provide the theoretic foundation of antiangiogenic therapy by describing the biology of angiogenesis as it applies to brain tumors. We then outline experimental antiangiogenic therapies that are being applied preclinically to brain tumors, as well as published clinical trial data and ongoing clinical trials in patients. Primary and metastatic brain tumors are covered, although there is far less exploration in the literature of brain metastases.